Psycho-physical stress and oxidative stress in athletes: by the medical staff of Juventus Football Club an interesting research on the d-ROMs Test

He completed almost 14 years the first scientific work published on the d-ROMs Test in d-ROMs Test in Sports Medicine.

We want to celebrate this event, reporting the results of a recent survey conducted by the medical staff of Juventus Football Club and published in the prestigious Journal of the International Society of Sports Nutrition .

In practice, Italian researchers have monitored the level of stress suffered by players during last season subjecting athletes to the determination of the ratio testosterone / cortisol in saliva and the evaluation of oxidative stress, by d-ROMs Test and OXY-Adsorbent Test on blood samples. The two parameters are strongly correlated, indicating a possible correlation between the levels of emotional stress and oxidative stress, although conceptually different from each other but both related to physical activity intense.

These data can be correctly interpreted in the light of the complex interrelationships that exist between neurons, lymphocytes and hormones,  object of the so-called PNEI (psiconeuroendocrinoimmunologia). In practice, strenuous physical exercise, especially if performed incorrectly in intensity and / or duration, can lead to an imbalance of neuro-transmitter (mainly serotonin) and a parallel increase in the levels of free radicals and pro-inflammatory cytokines. It has great importance not only in understanding the fatigue of athletes, but also the much dreaded "fatigue", typical of chronic and degenerative diseases, including cancer.

To satisfy your curiosity in the field we decided to make available, next to the original work cited, an updated selection of scientific articles published in 14 years of studies on the Panel Carratelli for Sports Medicine, all courtesy International Observatory of Oxidative Stress.

It is also possible request a specific contribution on the relationship between oxidative stress and sports writing to This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

Attachments

Angelini F, Buonocore D, Rucci S, Stesina G, Stefanini L, Bonuccelli A, Tencone F, Marzatico F. Oxidative stress vs hormonal profile in plasma and saliva: application in sport performance. J Internat Soc Sports Nutr. 2011. 8 (Suppl 1): P34.

Updated selection of scientific articles in Sports Medicine with Panel Carratelli

Animals at risk oxidative stress: alarm of the Department of Health !

Even the animals escape the effects, positive and negative, of free radicals. A unique international scientific literature, accumulated over the last ten years, especially with the Panel Carratelli, documents it very clear.

For example, Labradors, widely used to search for people in the rubble after a natural disaster or for the detection of explosives in the context of the prevention of terrorism, exhibit values ​​of d-ROMs Test well below those recorded in people. Probably because during evolution they have retained the ability to produce vitamin C, a powerful antioxidant, directly from glucose (Pasquini and Iorio, 2008). And it is for this reason that we, unlike dogs, are forced to take this precious nutrient from the outside through the fruits and vegetables.

Thus, "fishing" from our database, we are aware that there are now numerous animal species that we know the reference values ​​of the d-ROMs Test and, in many cases, also of OXY-Adsorbent Test: from fish to birds, from sheep to cattle, from rodents to pigs. Singular is the study, for example, through these analytical tools, of a vast colony of penguins in Anctartica.

The novelty is that now the Department of Health in Italy, in the National Integrated Plan 2011-214, has officially add the d-ROMs Test and the OXY-Adsorbent Test (with the codes, respectively, NK 2324 and NK 2325), in the internal accredited tests to evaluate the animal welfare (see here). The reference laboratories for carrying out the evaluations are those of the Headquarters of the Institute Zooprophylactic of Lombardy and Emilia Romagna (Brescia).

Interviewed in this regard, Eugenio Luigi Iorio, president of the International Observatory of Oxidative Stress - which is in constant contact with the National Institute of Health - said that "the time is now ripe for a similar official recognition of these methods even in  human, where the experimental and clinical evidence in favor are much higher than those found in Zooprophylactic field.  Paradoxically, Health Institutions  have not yet activated in a reasonable manner. "

At least for now, anyway, thanks to the opportunity to assess oxidative stress, our four-legged friends, but also farm animals, can sleep more peacefully. And us with them.

Alarm neurodegenerative diseases: guilty of oxidative stress?  The case "Parkinson"


Neurodegenerative diseases are a heterogeneous group of neurological diseases, with frequent muscle involvement. They are characterized by an insidious onset and a course of development which can lead capriciously, sometimes even short time, a severe impairment of normal vital functions such as phonation, breathing, swallowing and walking.

We ascribe to them the dementia of Alzheimer, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's, etc..

Many hypotheses have been formulated to try to explain why the incidence of these diseases is worrying increase and the oxidative stress seems to be among the most reliable.

In fact, the brain-spinal axis, is in itself highly susceptible to oxidative insults for a number of reasons. The first is due to its own metabolism, based almost exclusively on oxygen consumption, one of the "parents" of dangerous free radicals. In addition, the membranes of neurons, already prone to accumulate antioxidants such as vitamin E, have many polyunsaturated fatty acids that are a primary target of the radical attack . In the case of Parkinson's disease, then, is the metabolism of the neurotransmitter itself (the dopamine), which are deficient patients who are affected, to be sources of metabolites "oxidants".

Of these issues speaked to Arenzano (Italy), December 21, dr. Eugenio Luigi Iorio, president of the International Observatory of Oxidative Stress, in an important course for neurologists.

The occasion was propitious for the presentation of the results of a recent study performed in Cilento (Salerno, Italy) on a group of patients with Parkinson's disease showed that, compared with controls, significantly higher values ​​of oxidative stress, measured by d-ROMs Test.

A direct confirmation of how devastating it can be the effect of an uncontrolled production of reactive chemical species but also, perhaps, the real hope of being able to slow down, in the near future, the evolution progressive of this disease, promoting rational and targeted physiological modulators with antioxidant action.

Lower values ​​of d-ROMs Test in cystic fibrosis after intake whey protein.

This is one of the most interesting data to emerge from a study published in the latest issue of the prestigious journal "Progress in Nutrition," now available in digital version.

The book, dedicated to the whey protein and born from the collaboration of international experts, is divided into three sections.
The first section is devoted to the biochemical aspects, the second to clinical aspects, in accordance with the most current scientific literature, and the third to the results of recent trials conducted in Italy with the use of these precursors of "physiological modulators" in the field of pathology chronic-degenerative diseases.

The proteins from whey, after the pioneering observations by Italian-Canadian Gustavo Bounous (in the seventies), are now entering in the scene of the most popular supplements for nutritionists, especially in the area of ​​supportive care. One of the secrets of the effectiveness of these proteins is that they are rich in cysteine ​​and cystine, the natural precursor of glutathione, that is the most important intracellular antioxidant. In fact, in one of the trials reported in the last section of the work in question, performed at the Gaslini Institute of Genoa, the treatment with a special formula based on whey proteins delipidized and delactosed  (Prother^TM ) was accompanied by a statistically significant lower values ​​of d-ROMs Test in patients with cystic fibrosis (De Alessandri, Minicucci, Iorio et al.).

This study confirms once again the reliability of the Panel Carratelli to monitor the oxidative balance, especially in relation to supplementation.